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Gadolinium oxide nanoparticles (GNPs) show dual-mode imaging capabilities for cancer theranosis. These nanoparticles offer enhanced X-ray absorption and MRI relaxivity compared to commercial agents.

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Area of Science:

  • Nanotechnology
  • Biomedical Imaging
  • Materials Science

Background:

  • Gadolinium (Gd) is a versatile element with applications in MRI, CT, and cancer therapy.
  • Gadolinium oxide nanoparticles (GNPs) offer high Gd content for enhanced theranostic potential.

Purpose of the Study:

  • To explore the T1 MRI and CT dual imaging capabilities of iodine compound-coated GNPs (IC-GNPs).
  • To evaluate IC-GNPs as potential contrast agents for simultaneous diagnosis and therapy.

Main Methods:

  • Synthesis of various iodine compound (IC) coated GNPs (IC-GNPs).
  • Characterization of X-ray absorption and longitudinal water proton relaxivity (r1, r2/r1) of IC-GNPs.
  • In vivo T1 MR and CT imaging in mice.

Main Results:

  • IC-GNPs exhibited superior X-ray absorption compared to commercial agents.
  • IC-GNPs demonstrated higher longitudinal water proton relaxivities (r1 = 26-38 s⁻¹ mM⁻¹, r2/r1 = 1.4-1.9).
  • Successful in vivo T1 MR and CT imaging was achieved using IC-GNPs.

Conclusions:

  • IC-GNPs function as effective dual imaging agents for T1 MRI and CT.
  • GNPs hold promise for cancer theranosis, combining diagnostic and therapeutic applications.