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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Modified-Release Drug Delivery Systems: Overview01:19

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Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
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Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Cubosomes: Innovative Nanostructures for Drug Delivery.

Aindrilla S Duttagupta1, Harsiddhi M Chaudhary, Kisan R Jadhav

  • 1University of Mumbai, Bharati Vidyapeeth's College of Pharmacy, Department of Pharmaceutics, CBD Belapur, Sector-8, Navi-Mumbai-400614, India. aindrilla.dg@gmail.com.

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Cubosomes, advanced lipid nanoparticles, offer enhanced drug delivery by improving bioavailability and enabling sustained release. These versatile carriers protect drugs and are ideal for various therapeutic applications.

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Amphiphilic lipids self-assemble into bicontinuous cubic liquid crystalline phases in aqueous media.
  • Cubosomes, dispersions of inverted cubic phases, feature a lipid bilayer capable of incorporating diverse drug polarities.
  • These biocompatible nanoparticles represent a promising advancement in drug delivery systems.

Purpose of the Study:

  • To review the scope and importance of cubosomes as effective drug delivery vehicles.
  • To discuss cubosome preparation, drug loading/release, and characterization methods.
  • To summarize current advances in cubosome applications for various medical and cosmetic uses.

Main Methods:

  • Review of literature on cubosome preparation techniques.
  • Analysis of drug loading and release kinetics from cubosomal dispersions.
  • Examination of characterization methods for cubosomal formulations.
  • Overview of diverse application areas including drug delivery, burn management, and theranostics.

Main Results:

  • Cubosomal dispersions enhance drug bioavailability, particularly for poorly water-soluble drugs.
  • They reduce adverse effects, improve intracellular penetration, and protect drugs from degradation.
  • Sustained drug release and the inherent biodegradability of lipids are significant advantages.

Conclusions:

  • Cubosomes are proposed as novel carriers for advanced drug delivery systems due to their desirable properties.
  • Their capabilities in solubilizing, encapsulating, transporting, and protecting drugs make them attractive for in vivo applications.
  • Cubosomes offer a versatile platform for various drug delivery routes and therapeutic interventions.