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Hyperbaric oxygen in the treatment of calciphylaxis: A case series and literature review

Jennifer An1, Bridget Devaney2, Khai Yang Ooi1

  • 1Department Renal Medicine, Alfred Hospital, Melbourne, Victoria, Australia.

Nephrology (Carlton, Vic.)
|February 25, 2015
PubMed

Insights

Hyperbaric oxygen therapy (HBOT) shows promise for treating calcific uraemic arteriolopathy (CUA), also known as calciphylaxis. Over half of patients receiving HBOT experienced wound healing and improved survival, with diabetes being a key predictive factor.

Area of Science:

  • Nephrology
  • Dermatology
  • Vascular Surgery

Background:

  • Calcific uraemic arteriolopathy (CUA), or calciphylaxis, is a severe condition often seen in end-stage renal disease patients.
  • CUA is characterized by significant morbidity and mortality, posing a challenge in treatment.
  • Identifying effective therapies for CUA is crucial for improving patient outcomes.

Purpose of the Study:

  • To evaluate the efficacy of hyperbaric oxygen therapy (HBOT) in healing CUA lesions.
  • To identify patient-specific factors that predict wound healing and survival in CUA patients treated with HBOT.

Main Methods:

  • Retrospective review of CUA patients treated with HBOT at the institution.
  • Documentation of clinical and biochemical parameters, lesion characteristics, wound outcomes, and survival.
  • Analysis of patient data to determine factors associated with treatment success.

Main Results:

  • 46 patients with renal failure-associated CUA were identified; 34 completed HBOT.
  • 58% of patients receiving HBOT showed wound improvement, with over half achieving complete healing.
  • Patients benefiting from HBOT survived over 3 years on average; diabetes was linked to better outcomes.

Conclusions:

  • HBOT appears to be a beneficial treatment for CUA, improving wound healing and survival rates.
  • More than half of patients undergoing HBOT experienced positive outcomes, including extended survival.
  • Diabetes emerged as a significant predictor of improved wound healing and survival in CUA patients treated with HBOT.
Abstract

Keywords:
calciphylaxiscalcium phosphate productend-stage kidney diseasehyperbaric oxygenhyperparathyroidism

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