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Neuroprotection in ischemic stroke: what does the future hold?
Amos D Korczyn1, Michael Brainin, Alla Guekht
1Department of Neurology, Tel Aviv University, Ramat Aviv 69978, Israel.
Expert Review of Neurotherapeutics
|February 25, 2015
Summary
Most elderly patients experience mixed dementia, combining neurodegenerative and vascular issues. Multimodal therapies and lifestyle interventions show promise for treating cognitive impairment and preventing stroke.
Area of Science:
- Neurology
- Geriatrics
- Vascular Medicine
Background:
- Concurrent neurodegenerative and vascular diseases complicate diagnosis of cognitive impairment in the elderly.
- Mixed dementia is common, necessitating therapies with multimodal actions for neuronal protection.
Discussion:
- Ischemic stroke presents complex pathophysiology and leads to significant post-stroke cognitive impairment.
- Translating neuroprotective treatments from bench to bedside remains challenging, with mixed clinical trial results.
Key Insights:
- Emerging drug therapies, including natural biologicals like Actovegin, are being tested for neuroprotection.
- Multifaceted biological molecules show potential in the restorative phase following ischemia.
- Non-pharmacological interventions, particularly lifestyle changes, are crucial for stroke treatment and prevention.
Outlook:
- Future research focuses on prospective, randomized, controlled studies for novel therapeutic agents.
- Combination therapies integrating pharmacological and lifestyle interventions are expected to improve outcomes.
- Personalized treatment strategies may address the complexity of mixed dementia and post-stroke cognitive impairment.
