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Updated: Apr 17, 2026
Chronic Transcranial Electrical Stimulation and Intracortical Recording in Rats
Published on: May 11, 2018
The use of automated system for EEG analysis and feedback cerebral stimulation to stop epileptiform activity in
V A Blik1, A V Aristov, N E Chepurnova
1Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia, vitaliyablik@gmail.com.
Abstract:
Original software program is described, which revealed EEG activity characteristic of the onset of epileptic seizure and turned on electrical stimulation of the nucleus basalis of Meynert in WAG/Rij rats with congenital absence epilepsy. The program reliably detected the onset of seizure and automatically stopped it with a high-frequency train of electrical impulses (100-150 Hz). Thus, a feedback system of deep brain stimulation has been developed to stop early manifestations of absence epileptiform seizures. The study can be a base to develop an implanted apparatus to automatically analyze EEG and stimulate the brain to stop the epileptic seizures.
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