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Drug-induced skin reactions: a 2-year study
Mahmood Farshchian1, Akram Ansar1, Abbas Zamanian2
1Psoriasis Research Center, Department of Dermatology, Farshchian Hospital, Hamadan University of Medical Sciences, Hamedan, Iran.
Clinical, Cosmetic and Investigational Dermatology
|February 25, 2015
Summary
Adverse cutaneous drug reactions are often caused by beta-lactam antibiotics and NSAIDs. Acute urticaria and fixed drug eruptions are the most frequent presentations of these reactions.
Area of Science:
- Dermatology
- Pharmacology
- Clinical Medicine
Background:
- Adverse cutaneous drug reactions (ACDRs) are a significant cause of drug-related morbidity.
- Understanding the clinical characteristics of ACDRs is crucial for patient management.
Purpose of the Study:
- To analyze the clinical characteristics of patients experiencing adverse cutaneous drug reactions.
- To identify common drug classes and clinical presentations associated with ACDRs.
Main Methods:
- Retrospective analysis of 308 patients diagnosed with ACDRs between 2007 and 2009.
- Histopathologic examination of skin biopsies performed in 84 cases.
Main Results:
- Females represented 63% of patients with ACDRs.
- Beta-lactam antibiotics (42.7%) and non-steroidal anti-inflammatory drugs (NSAIDs) (16.5%) were the most frequent causative agents.
- Acute urticaria (59.2%), fixed drug eruptions (18.5%), and maculopapular eruptions (14.9%) were the most common clinical presentations.
Conclusions:
- Beta-lactam antibiotics and NSAIDs are primary inducers of ACDRs in this population.
- Acute urticaria, fixed drug eruptions, and maculopapular rashes are the predominant forms of ACDRs.
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