Related Experiment Video
Updated: Apr 17, 2026
14:39
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
32.7K
Anti-IL5 therapy for asthma and beyond.
Manali Mukherjee1, Roma Sehmi1, Parameswaran Nair1
1St Joseph's Healthcare & Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6 Canada.
The World Allergy Organization Journal
|February 25, 2015
Summary
Novel biologics targeting interleukin-5 (IL-5) show mixed results for asthma. Identifying specific patient endotypes and exploring alternative mechanisms are crucial for improving treatments for eosinophilic airway inflammation.
Area of Science:
- Immunology
- Pulmonology
- Pharmacology
Background:
- Airway inflammation drives the severity and heterogeneity of respiratory disorders.
- Interleukin-5 (IL-5) is a key cytokine in eosinophilic airway inflammation.
- Current anti-IL-5 biologics demonstrate variable efficacy in asthma patients.
Purpose of the Study:
- To evaluate the therapeutic potential of anti-IL-5 biologics.
- To investigate the importance of patient endotyping for IL-5 targeted therapies.
- To explore alternative mechanisms of tissue eosinophilia beyond current anti-IL-5 treatments.
Main Methods:
- Review of post hoc analyses from clinical trials involving anti-IL-5 agents.
- Examination of data on the use of anti-IL-5 treatments in conditions beyond asthma.
- Analysis of mechanisms contributing to tissue eosinophilia.
Main Results:
- Anti-IL-5 therapies show mixed results in asthma, highlighting the need for endotype identification.
- These therapies are being considered for hypereosinophilic syndrome (HES) and eosinophilic granulomatosis and polyangitis (EGPA).
- Existing anti-IL-5 approaches may not fully address all mechanisms of tissue eosinophilia.
Conclusions:
- Identifying IL-5-responsive endotypes is critical for optimizing anti-IL-5 therapy in asthma.
- Anti-IL-5 biologics hold promise for eosinophilic conditions like HES and EGPA.
- Further research is needed to address alternative pathways of tissue eosinophilia for improved treatment strategies.
Keywords:
BenralizumabChronic bronchitisChronic obstructive pulmonary disorder (COPD)Churg-strauss syndromeEosinophilEosinophilic asthmaEosinophilic granulamatosis and polyangitis (EGPA)Hypereosinophilic syndrome (HES)IL-5MepolizumabReslizumabMore Related Videos
Related Concept Videos
01:19Antiasthma Drugs: Leukotriene Modifiers
2.3K
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
2.3K
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
2.4K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.4K
01:20Asthma: Pathogenesis and Management
1.7K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.7K
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
2.1K
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
2.1K
01:30Asthma-IV: Diagnostic and Management
3.4K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.4K
01:26Asthma-II: Pathophysiology and Classification
5.0K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
5.0K