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Related Experiment Video

Updated: Apr 17, 2026

Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography
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Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography

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Macular thickness and amblyopia.

Zhale Rajavi1, Hossein Moghadasifar1, Mohadese Feizi1

  • 1Department of Ophthalmology, Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Journal of Ophthalmic & Vision Research
|February 25, 2015
PubMed
Summary

Macular thickness in children with amblyopia was mostly similar, but moderate to severe amblyopia showed greater foveolar thickness compared to controls. Further research is recommended.

Keywords:
AmblyopiaMacular ThicknessOptical Coherence Tomography

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Comparison of Three Clinical Stereoscopic Methods for Measuring Binocular Visual Function During Amblyopic Treatment in Unilateral Amblyopia
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Area of Science:

  • Ophthalmology
  • Pediatric Ophthalmology
  • Vision Science

Background:

  • Functional amblyopia affects visual development in children.
  • Optical coherence tomography (OCT) is a key imaging technique in ophthalmology.
  • Understanding macular structure in amblyopia is crucial for diagnosis and treatment.

Purpose of the Study:

  • To compare macular thickness in children with and without functional amblyopia using OCT.
  • Investigate differences in central macular thickness (CMT) and foveal thickness.

Main Methods:

  • A case-control study involving 93 children (aged 3-10 years) with unilateral amblyopia (44 cases) and without amblyopia (49 controls).
  • OCT was used to measure macular thickness at the foveola, 1 mm ring (fovea), and 3/6 mm rings.
  • Amblyopic eyes served as cases, fellow eyes as internal controls, and non-amblyopic eyes as external controls.

Main Results:

  • No general difference in macular thickness between amblyopic and non-amblyopic groups.
  • Significant difference in central macular thickness between moderate-to-severe amblyopic eyes and external controls (P=0.037).
  • Greater foveal thickness difference (>10 microns) between fellow eyes in amblyopic children (P=0.002); boys had greater foveal thickness (P=0.037).

Conclusions:

  • No significant overall relationship found between macular thickness and amblyopia.
  • Foveolar thickness was significantly greater in moderate-to-severe amblyopic eyes compared to external controls.
  • Further studies with larger cohorts of moderate-to-severe amblyopia are warranted.