Related Experiment Video
Updated: Apr 17, 2026
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Sterile Keratitis following Collagen Crosslinking
Mohammad-Ali Javadi1, Sepehr Feizi1
1Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Purpose:
To report a keratoconic eye that developed severe sterile keratitis and corneal scar after collagen crosslinking necessitating corneal transplantation.
Case Report:
A 26-year-old man with progressive keratoconus underwent collagen crosslinking and presented with severe keratitis 72 hours after the procedure. The initial impression was infectious corneal ulcer and a fortified antibiotic regimen was administered. However, the clinical course and confocal microscopy results prompted a diagnosis of sterile keratitis. The eye developed severe corneal scars leading to reduced visual acuity and necessitating corneal transplantation.
Conclusion:
Sterile keratitis may develop after collagen crosslinking resulting in profound visual loss leading to corneal transplantation.
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