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Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
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Sterile Keratitis following Collagen Crosslinking.

Mohammad-Ali Javadi1, Sepehr Feizi1

  • 1Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Journal of Ophthalmic & Vision Research
|February 25, 2015
PubMed
Summary

Severe sterile keratitis and corneal scarring can occur after collagen crosslinking for keratoconus, potentially leading to corneal transplantation and vision loss.

Keywords:
Collagen CrosslinkingKeratoconusSterile Keratitis

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Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Ocular Surface Disease

Background:

  • Collagen crosslinking is a standard treatment for progressive keratoconus.
  • Complications, though rare, require careful monitoring and management.
  • Understanding post-procedural inflammatory responses is crucial.

Observation:

  • A 26-year-old male with progressive keratoconus developed severe keratitis 72 hours post-collagen crosslinking.
  • Initial presentation mimicked infectious keratitis, treated with antibiotics.
  • Confocal microscopy confirmed sterile keratitis, not an infection.

Findings:

  • The patient developed significant corneal scarring and reduced visual acuity.
  • The severe keratitis necessitated a corneal transplantation.
  • This case highlights a severe, sight-threatening complication of collagen crosslinking.

Implications:

  • Sterile keratitis is a potential complication of collagen crosslinking.
  • Prompt diagnosis and management are vital to prevent profound visual loss.
  • Corneal transplantation may be required in severe cases, underscoring the need for vigilance.