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Recurrent seizures after lidocaine ingestion
Hamed Aminiahidashti1, Abolghasem Laali1, Nazanin Nosrati1
1Department of Emergency, Mazandaran University of Medical Sciences, Sari, Iran.
Journal of Advanced Pharmaceutical Technology & Research
|February 25, 2015
Summary
Accidental ingestion of lidocaine in a child led to central nervous system (CNS) toxicity and seizures. Conservative management was effective for this lidocaine-induced seizure case.
Area of Science:
- Toxicology
- Pediatric Neurology
Background:
- Lidocaine exhibits a concentration-dependent effect on seizure activity.
- Elevated lidocaine concentrations (above 15 μg/mL) are frequently associated with seizures in both animal models and humans.
Observation:
- A case report details a 4-year-old boy experiencing recurrent generalized tonic-clonic seizures following accidental ingestion of a 2% lidocaine hydrochloride solution.
- The child presented with seizures approximately 30 minutes after ingesting 20-25 cc of the solution, mistaking it for pediatric gripe medicine.
Findings:
- Neurological examination revealed a depressed level of consciousness, but computed tomography scans showed no intracranial lesions.
- The patient experienced three seizures at home but none after admission, with a stable condition allowing discharge after two days.
Implications:
- This case highlights the potential for cardiovascular and central nervous system (CNS) toxicity from viscous lidocaine, especially in pediatric populations.
- Conservative management approaches are recommended as the optimal treatment strategy for lidocaine-induced seizures.
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