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Metal oxide-coating PMMA or Talc as a new IR blocker inhibits IR-induced decrease of collagens in human dermal
1Cosmax R&I Center, 602, Pangyo inno valley E, 255, Pangyo-ro, Bungdang-gu, Seongnam-si, Gyeonggi-do, Korea.
International Journal of Cosmetic Science
|February 26, 2015
Summary
Polymethyl methacrylate (P/M) or Talc (T/M) coatings effectively block near-infrared (NIR) radiation, preventing collagen degradation in human dermal fibroblasts by inhibiting heat transmission.
Area of Science:
- Dermatology
- Materials Science
- Biochemistry
Background:
- Infrared (IR) radiation can induce collagen degradation in human dermal fibroblasts.
- Metal oxides are effective inorganic molecules for intercepting IR radiation.
Purpose of the Study:
- To investigate whether Polymethyl methacrylate (P/M) or Talc (T/M) coatings inhibit IR-induced collagen decrease in human dermal fibroblasts.
- To assess the efficacy of P/M and T/M as near-IR (NIR) blockers.
Main Methods:
- Developed P/M and T/M as novel IR blockers using metal oxide coatings.
- Measured gene and protein expressions of procollagens and matrix metalloproteinases (MMPs) in IR-irradiated Hs68 cells.
- Evaluated the effect of P/M and T/M on cell media temperature under IR irradiation.
Main Results:
- P/M and T/M significantly blocked NIR transmittance.
- Both P/M and T/M inhibited IR-induced increases in MMP-1, MMP-3, and MMP-9.
- IR-induced decreases in type 1 and 4 procollagen were inhibited by P/M and T/M in a dose-dependent manner.
- P/M and T/M blocked IR lamp-induced temperature increases in cell media.
Conclusions:
- P/M and T/M effectively inhibit collagen decrease by blocking IR-induced heat transmission.
- These novel IR blockers show potential for protecting human dermal fibroblasts from IR-induced damage.
