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Updated: Mar 14, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
Published on: August 15, 2019
Using Markov chains of nucleotide sequences as a possible precursor to predict functional roles of human genome: a
K-E Lee1, E-J Lee1, H-S Park2,3
1Bioinformatics Laboratory, Engineering School, Ewha Womans University, Seoul, Korea.
Abstract:
Recent advances in computational epigenetics have provided new opportunities to evaluate n-gram probabilistic language models. In this paper, we describe a systematic genome-wide approach for predicting functional roles in inactive chromatin regions by using a sequence-based Markovian chromatin map of the human genome. We demonstrate that Markov chains of sequences can be used as a precursor to predict functional roles in heterochromatin regions and provide an example comparing two publicly available chromatin annotations of large-scale epigenomics projects: ENCODE project consortium and Roadmap Epigenomics consortium.
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