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Updated: Apr 16, 2026

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
Published on: October 25, 2024
Combined imaging of oxidative stress and microscopic structure reveals new features in human atherosclerotic plaques
Magnus B Lilledahl1, Håkan Gustafsson2, Pål Gunnar Ellingsen1
1Norwegian University of Science and Technoogy, Department of Physics, 7491 Trondheim, Norway.
Abstract:
Human atherosclerotic samples collected by carotid endarterectomy were investigated using electronic paramagnetic resonance imaging (EPRI) for visualization of reactive oxygen species, and nonlinear optical microscopy (NLOM) to study structural features. Regions of strong EPRI signal, indicating a higher concentration of reactive oxygen species and increased inflammation, were found to colocalize with regions dense in cholesterol crystals as revealed by NLOM.
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