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Updated: Apr 16, 2026

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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
Published on: February 27, 2016
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Sirtuin inhibitor sirtinol is an intracellular iron chelator
R Gautam1, E A Akam, A V Astashkin
1University of Arizona, Department of Chemistry and Biochemistry, 1306 E. University Blvd., Tucson AZ 85721, USA. tomat@email.arizona.edu.
Abstract:
Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda.

