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Related Experiment Videos

Hyperreactio luteinalis in normal singleton pregnancy.

M Okadome1, T Kaku, N Tsukamoto

  • 1Department of Gynecology and Obstetrics, Kyushu University Faculty of Medicine, Fukuoka, Japan.

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|August 1, 1989
PubMed
Summary

Hyperreactio luteinalis, a rare ovarian enlargement, occurred in a healthy pregnancy. Elevated maternal androgens resolved after ovarian surgery, with no impact on the female infant.

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Area of Science:

  • Reproductive Endocrinology
  • Maternal-Fetal Medicine
  • Gynecologic Pathology

Background:

  • Hyperreactio luteinalis is a rare condition characterized by bilateral luteinization of the ovaries.
  • It is typically associated with conditions of increased human chorionic gonadotropin (hCG), such as multiple gestation or hydatidiform mole.
  • This report details a case occurring in a normal singleton pregnancy.

Observation:

  • A pregnant patient presented at 24 weeks' gestation with abdominal pain and signs of virilization.
  • Physical examination revealed enlarged ovaries.
  • The patient delivered a healthy female infant at 39 weeks' gestation without signs of masculinization.

Findings:

  • Maternal serum levels of testosterone, delta 4-androstene-dione, and 5 alpha-dihydrotestosterone were significantly elevated.

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  • These androgen levels remained high postpartum but normalized after partial resection of the enlarged ovaries.
  • Comparison with luteoma of pregnancy cases revealed distinct maternal serum androgen profiles.

    • Implications:

    • This case expands the understanding of hyperreactio luteinalis, demonstrating its occurrence in uncomplicated singleton pregnancies.
    • It highlights the importance of monitoring maternal androgen levels in suspected cases.
    • Surgical intervention may be necessary for symptom resolution and normalization of hormone levels.