[Neuroimmunological aspects of the pathogenesis of epilepsy]

The review is devoted to the analysis of neuroimmunological aspects of the pathogenesis of epilepsy. Discuss the pathogenetic role of proinflammatory cytokines, antibodies to antigens of the nervous tissue and neurotransmitters, such as dopamine, serotonin, glutamate and GABA in the pathogenesis of epilepsy. The focus of the review is given to clinical research, devoted to the interrelation of the severity of the disease and changes of immunological indices. Disorders of the immune system are most pronounced in drug-resistant forms of epilepsy. Describes the clinical and experimental research, which shows that the use of antiepileptic drugs improves immunity. The use of immunotherapy in combination with anti-epileptics drugs leads to positive results. Thus, the analysis of the immune status of patients with epilepsy can serve as an important criterion for determining the severity of the disease and the appointment of adequate treatment. The authors analyze their own data of anticonvulsant activity of antibodies to glutamate and opposite proconvulsant effect of antibodies to GABA.