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Related Experiment Video

Updated: Apr 16, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

Bronchiectasis.

Cecile Magis-Escurra¹, Monique He Reijers

¹Radboud University Medical Centre, Radboud University, Nijmegen, The Netherlands.

BMJ Clinical Evidence

|February 27, 2015

Summary

This summary is machine-generated.

This systematic review evaluates treatments for non-cystic fibrosis bronchiectasis, finding evidence on airway clearance, inhaled corticosteroids, exercise, hyperosmolar agents, mucolytics, antibiotics, and surgery.

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Area of Science:

Pulmonology
Respiratory Medicine
Clinical Evidence Synthesis

Background:

Bronchiectasis is a chronic respiratory condition often resulting from infection or inflammation.
It is characterized by chronic cough, sputum production, and recurrent infections.
Bronchiectasis can coexist with or resemble conditions like asthma and COPD, but excludes cystic fibrosis in this review.

Purpose of the Study:

To systematically review and synthesize the evidence on the effects of various treatments for non-cystic fibrosis bronchiectasis.
To assess the effectiveness and safety of different therapeutic interventions.
To answer the clinical question regarding treatment outcomes in this patient population.

Main Methods:

A systematic literature review was conducted, searching major medical databases up to January 2014.
Included studies focused on treatments for non-cystic fibrosis bronchiectasis.
Evidence quality was evaluated using the GRADE system, and harms alerts were incorporated.

Main Results:

Twenty-three studies met the inclusion criteria for the systematic review.
The review identified and analyzed data on several key interventions.

Conclusions:

The review presents findings on the effectiveness and safety of multiple treatments for non-cystic fibrosis bronchiectasis.
Interventions covered include airway clearance techniques, inhaled corticosteroids, exercise, inhaled hyperosmolar agents, mucolytics, prolonged-use antibiotics, and surgery.