[Current Topics on Vitamin D. Influences of vitamin D on muscle cells and function]

Vitamin D deficiency is associated with sarcopenia, which is characterized by the decrease in muscle mass and the muscle weakness. Active form of vitamin D binds to nuclear or non-nuclear vitamin D receptor (VDR) and regulates the proliferation and differentiation of myoblasts through its genomic or non-genomic actions. Clinical evidence showed the beneficial effects of vitamin D treatment on muscle mass and function in older people. Recent studies suggest that vitamin D is associated with the preservation of muscle function related to the interactions between bone and muscle.