Related Experiment Video
Updated: Apr 16, 2026
08:46
Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
Published on: September 1, 2015
10.3K
CKD and Its Risk Factors among Patients with Cystinuria
Caroline Prot-Bertoye1, Saïd Lebbah1, Michel Daudon1
1Due to the number of contributing authors,the affiliations are provided in the Supplemental Material.
Clinical Journal of the American Society of Nephrology : CJASN
|February 27, 2015
Summary
Cystinuria frequently leads to chronic kidney disease (CKD) and high blood pressure (BP) in patients. Routine screening for these conditions is crucial for managing cystinuria complications.
Area of Science:
- Nephrology
- Urology
- Genetics
Background:
- Cystinuria is an autosomal recessive disorder impacting renal cystine reabsorption.
- It is a significant cause of kidney stones in both adults and children.
Purpose of the Study:
- To investigate the epidemiologic and clinical features of cystinuria.
- To identify comorbidities, specifically chronic kidney disease (CKD) and high blood pressure (BP), in cystinuric patients.
Main Methods:
- A retrospective study involving 442 cystinuric patients across 47 French centers.
- Data collected from April 2010 to January 2012.
Main Results:
- The median age of symptom onset was 16.7 years, with a median diagnostic delay of 1.3 years.
- Among patients aged 16 years or older, 28.6% had high BP, and varying degrees of reduced estimated glomerular filtration rate (eGFR) were observed.
- CKD was associated with age, hypertension, and severe renal parenchymal damage; hypertension was linked to age, male sex, and reduced eGFR.
Conclusions:
- Chronic kidney disease (CKD) and high blood pressure (BP) are common in cystinuria patients.
- Regular screening for CKD and high BP is recommended for individuals with cystinuria.
Related Concept Videos
01:25Chronic Kidney Disease I: Introduction
1.2K
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1.2K
01:28Urinary Tract Calculi I: Introduction
988
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
988
01:24Chronic Kidney Disease II: Clinical Manifestations
1.1K
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
1.1K
01:28Chronic Kidney Disease III: Interprofessional Care
651
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
651
01:27Urinary Tract Calculi IV: Nutrition Therapy and Prevention
704
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
704
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
518
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
518