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Updated: Apr 16, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
The influence of life events on first and recurrent admissions in bipolar disorder
Sanne M Kemner1, Neeltje Em van Haren1, Florian Bootsman1
1Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, A00.241, PO Box 85500, 3508 GA Utrecht, The Netherlands.
Background:
Life events play an important role in the onset and course of bipolar disorder. We will test the influence of life events on first and recurrent admissions in bipolar disorder and their interaction to test the kindling hypothesis.
Methods:
We collected information about life events and admissions across the life span in 51 bipolar patients. We constructed four models to explore the decay of life event effects on admissions. To test their interaction, we used the Andersen-Gill model.
Results:
The relationship between life events and admissions was best described with a model in which the effects of life events gradually decayed by 25% per year. Both life event load and recurrent admissions significantly increased the risk of both first and subsequent admissions. No significant interaction between life event load and number of admissions was found.
Conclusions:
Life events increase the risk of both first and recurrent admissions in bipolar disorder. We found no significant interaction between life events and admissions, but the effect of life events on admissions decreases after the first admission which is in line with the kindling hypothesis.
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