Related Experiment Video
Updated: Apr 16, 2026
An Automated Microscopic Scoring Method for the γ-H2AX Foci Assay in Human Peripheral Blood Lymphocytes
Published on: December 25, 2021
Exposure Reconstruction and Risk Analysis for Six Semiconductor Workers With Lymphohematopoietic Cancers
Rachael M Jones1, Linda Dell, Craig Torres
1From ENVIRON International Corporation (Dr Jones, Ms Simmons, and Ms Boelter) and School of Public Health, University of Illinois at Chicago (Dr Jones); ENVIRON International Corporation (Ms Dell), Amherst, MA; ENVIRON International Corporation (Mr Torres), Atlanta, GA; ENVIRON International Corporation (Dr Poole), Tampa, FL; and ENVIRON International Corporation (Mr Harper), Phoenix, AZ. Ms Simmons is currently employed by Simmons Environmental and Occupational Health Solutions. Mr Torres is currently employed by Gates Rubber.
Objective:
To investigate whether workplace exposures to recognized lymphohematopoietic carcinogens were possibly related to cancers in six semiconductor-manufacturing workers.
Methods:
A job-exposure matrix was developed for chemical and physical process agents and anticipated by-products. Potential cumulative occupational exposures of the six cases were reconstructed. The role of workplace exposures in cancer was evaluated through quantitative risk assessment and by comparison with epidemiological literature.
Results:
Two workers were potentially exposed to agents capable of causing their diagnosed cancers. Reconstructed exposures were similar to levels in outdoor environments and lower than exposures associated with increased risks in epidemiological studies. Cancer risks were estimated to be less than 1 in 10,000 persons.
Conclusions:
The development of cancer among the six workers was unlikely to be explained by occupational exposures to recognized lymphohematopoietic carcinogens.
More Related Videos
09:40Quantitation and Analysis of the Formation of HO-Endonuclease Stimulated Chromosomal Translocations by Single-Strand Annealing in Saccharomyces cerevisiae
Published on: September 23, 2011
11:40A Co-culture Method to Investigate the Crosstalk Between X-ray Irradiated Caco-2 Cells and PBMC
Published on: January 30, 2018