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N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions

Nian Liu1, Qing Dai1, Guanqun Zheng2

  • 1Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA.

Nature
|February 27, 2015
PubMed
Summary

The N(6)-methyladenosine (m(6)A) modification acts as an "m(6)A-switch," altering RNA structure to control RNA-protein interactions. This mechanism regulates gene expression and RNA maturation by influencing RNA-binding protein access to RNA binding motifs.

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