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[Long-term benzodiazepine medication].

K L Wendland1, H Lucius

  • 1Universitäts-Nervenklinik Kiel.

Psychiatrische Praxis
|September 1, 1989
PubMed
Summary
This summary is machine-generated.

Benzodiazepine (BD) dependence is treatable, with most patients showing improvement after withdrawal. Long-term dependence is rare, indicating a low relapse tendency for benzodiazepine misuse.

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Medicine

Context:

  • Benzodiazepine (BD) misuse and dependence were significant issues during the 1970s and 1980s.
  • Withdrawal treatment was a primary intervention for patients with BD dependence.

Purpose:

  • To investigate the characteristics of patients with benzodiazepine (BD) misuse and dependence.
  • To evaluate the outcomes of withdrawal treatment for BD dependence.

Summary:

  • The study analyzed 80 patients undergoing BD withdrawal, with a majority being women often experiencing relationship and vocational difficulties.
  • Withdrawal symptoms, including delirium and seizures, occurred in 58 patients after Lorazepam or Bromazepam cessation.
  • Follow-up in 51 patients showed 20 required no further treatment, 18 relapsed, but only 3 remained physically and psychologically dependent, with 8 showing low-dose psychological dependence.

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Impact:

  • Findings suggest benzodiazepine (BD) dependence is remediable with withdrawal treatment.
  • BD dependence shows a low tendency for relapse after successful withdrawal.
  • The study highlights the effectiveness of withdrawal interventions for benzodiazepine (BD) misuse.