Engineering of a lipid-polymer nanoarchitectural platform for highly effective combination therapy of doxorubicin and
T Ramasamy1, H B Ruttala, J Y Choi
1College of Pharmacy, Yeungnam University, 214-1, Dae-dong, Gyeongsan, 712-749, South Korea. csyong@ynu.ac.kr jongohkim@yu.ac.kr.
Chemical Communications (Cambridge, England)
|February 28, 2015
Abstract:
We developed a highly stable lipid-polymer nanoarchitectural platform for effective combination therapy of doxorubicin and irinotecan in the polyelectrolyte complex nanoparticle core, followed by incorporation of the whole assembly into a lecithin bilayer. It shows great potential for the treatment of a broad range of cancers.
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