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Protein-loosing enteropathy in sclerosing mesenteritis
1Gastroenterology, Colorectal Surgery, Radiology, Pathology; Department of Clinical Medicine and Surgery, University "Federico II" of Naples, Italy. antoniorispo@email.it.
Abstract:
Sclerosing mesenteritis (SM) is a rare, idiopathic disorder of unknown aetiology that involves the adipose tissue of the mesentery, being characterized by chronic and non-specific fibrous inflammation. Patients usually present with non-specific clinical manifestations, such as abdominal pain and diarrhoea. The diagnosis of SM is difficult and it can be definitely established only by means of surgical or imaging-guided biopsy. Different therapeutic strategies have been used in case series with different rate of success. The disease is generally self-limiting, and the long-term prognosis is good, even if some cases of severe SM are reported in literature. Here, we report a fatal case of sclerosing mesenteritis associated to protein-losing enteropathy.
Insights
Sclerosing mesenteritis (SM) is a rare condition causing fibrous inflammation of the mesentery. This report details a fatal case of severe SM complicated by protein-losing enteropathy, highlighting potential severe outcomes.
Area of Science:
- Gastroenterology
- Pathology
- Rare Diseases
Background:
- Sclerosing mesenteritis (SM) is a rare idiopathic disorder characterized by chronic fibrous inflammation of the mesentery.
- It presents with non-specific symptoms like abdominal pain and diarrhea, making diagnosis challenging.
Observation:
- Diagnosis of SM typically requires biopsy, and various treatments show variable success rates.
- While often self-limiting with a good prognosis, severe cases of SM are documented.
Findings:
- This case report details a fatal instance of sclerosing mesenteritis.
- The severe SM was associated with protein-losing enteropathy, a rare complication.
Implications:
- This case underscores the potential for severe manifestations and fatal outcomes in sclerosing mesenteritis.
- It highlights the critical association between severe SM and protein-losing enteropathy, necessitating further investigation into this link.
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