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Limb deformity in a newborn. Is rifampicin just an innocent bystander?
T Kalayci1, T Erener-Ercan, G Buyukkale
1Department of Pediatrics, Department of Neonatology, Ministry of Health, Kanuni Sultan Suleyman Teaching and Research Hospital, Istanbul, Turkey. tugbaerener@yahoo.com.
Objective:
The first-line antituberculous agents for use during pregnancy have minimal teratogenic effects. The possibility of limb deformity during rifampin use, however, was reported by some researchers.
Case Report:
A male newborn was born with a hypoplastic right forearm to a mother with tuberculosis who used isoniazid and rifampicin in the first two months of her pregnancy.
Conclusions:
The limb anomaly in our case might be attributed to rifampicin usage during the first 2 months of pregnancy. Caution should be given with regard to possible congenital malformations which could be associated with the treatment of pregnant women with antituberculous drugs.
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