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Synthesis and Regulation of Thyroid Hormones01:20

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Circulating irisin concentrations in rat models of thyroid dysfunction -- effect of exercise.

Doaa M Samy1, Cherine A Ismail2, Rasha A Nassra3

  • 1Department of Medical Physiology, Faculty of Medicine, Al-Moassat Hospital, University of Alexandria, Alexandria, Egypt.

Metabolism: Clinical and Experimental
|February 28, 2015
PubMed
Summary

Thyroid dysfunction in rats elevates serum irisin, potentially due to oxidative stress. Acute exercise also boosts irisin, but chronic exercise shows no significant effect on irisin levels across different thyroid states.

Keywords:
ExerciseHyperthyroidHypothyroidIrisinOxidative stress

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Area of Science:

  • Endocrinology
  • Exercise Physiology
  • Metabolic Research

Background:

  • Irisin, a myokine, is investigated for its role in energy expenditure and potential therapeutic applications in metabolic diseases.
  • The impact of altered thyroid status and exercise on irisin regulation requires further elucidation.

Purpose of the Study:

  • To investigate the relationship between thyroid dysfunction (hyperthyroidism and hypothyroidism) and serum irisin levels in rats.
  • To examine the effect of acute and chronic exercise on serum irisin concentrations in rats with varying thyroid statuses.
  • To explore potential correlations between serum irisin and markers of metabolic derangement, oxidative stress, and myopathy.

Main Methods:

  • Serum irisin was quantified in male Wistar rats under sedentary conditions or following 8-week chronic swimming exercise.
  • Rats were induced into hyperthyroid or hypothyroid states.
  • Acute exercise effects on serum irisin were assessed in a separate cohort.

Main Results:

  • Sedentary hyperthyroid and hypothyroid rats exhibited significantly higher serum irisin concentrations compared to euthyroid controls.
  • Acute exercise led to a significant increase in serum irisin.
  • Chronic exercise did not significantly alter serum irisin levels across different thyroid profiles.
  • Serum irisin showed positive correlations with markers of oxidative stress and myopathy (creatine kinase, malondialdehyde) and negative correlations with reduced glutathione in pooled data, though these associations were not significant when analyzed separately.
  • No significant association was found between serum irisin and skeletal muscle mass, insulin resistance, blood glucose, lipids, or TSH.

Conclusions:

  • Both hyperthyroidism and hypothyroidism are associated with increased serum irisin in rats, possibly linked to oxidative damage and myopathy.
  • Acute exercise elevates serum irisin, potentially due to associated oxidative stress.
  • Serum irisin levels do not appear to be directly associated with metabolic abnormalities in thyroid dysfunction based on this study.