Related Experiment Video
Updated: Apr 16, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
The effect of obstructive sleep apnea syndrome on growth and development in nonobese children: a parallel study of
Xiao Man Zhang1, Jun Shi1, Guo Zhen Meng1
1Department of Otolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
Objective:
To explore the effects of obstructive sleep apnea syndrome (OSAS) on children's growth by the study of identical twins.
Study Design:
Seventeen cases of nonobese children with OSAS were included in this study. The control group was their identical twin sibling, who had no signs of OSAS. Data including height, weight, and serum insulin-like growth factor 1 levels were analyzed before tonsillectomy and adenoidectomy (T&A) and at 3, 6, and 12 months after surgery.
Results:
The mean apnea hyponea index was 3.9 times/hour in patients with OSAS and became normal after surgery. Minimum oxygen saturation gradually increased after T&A. The height and weight of the OSAS group before T&A was lower than the control group. During the follow-up period, height and weight increased but were lower than the control group. Serum insulin-like growth factor 1 levels in the OSAS group before T&A were lower than the control group. The level was significantly increased 3 months after T&A.
Conclusion:
OSAS impairs growth and development. Significant growth recovery occurs after T&A, and early surgical intervention is an important factor for improvement in growth.
More Related Videos
Related Concept Videos
Sleep Apnea
The condition is more prevalent among...
Nature and Nurture
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
Insufficient Sleep and Sleep Deprivation
Sleep deprivation is a more severe form of sleep loss...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Drug Dosing: Obese Patients

