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[Pathophysiology of sepsis].

Florian Uhle, Christoph Lichtenstern, Thorsten Brenner

    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
    |February 28, 2015
    PubMed
    Summary

    Sepsis is an immune system pathology, not just pro- or anti-inflammatory. It involves a complex immune response continuum, leading to dysfunction and susceptibility to secondary infections.

    Area of Science:

    • Immunology
    • Pathophysiology
    • Molecular Biology

    Context:

    • Sepsis understanding has evolved significantly.
    • Current view: sepsis as a host immune response to infection.
    • Immune response is a continuum, not solely pro- or anti-inflammatory.

    Purpose:

    • To review the molecular mechanisms of sepsis.
    • To explain the evolving understanding of sepsis pathophysiology.
    • To highlight the immune system's role in sepsis.

    Summary:

    • Sepsis is primarily an immune system pathology, triggered by infection but driven by the host's response.
    • It represents a continuum of immune mechanisms, shifting from overshooting reactions to immune dysfunction.
    • This immune dysfunction increases susceptibility to secondary infections.

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    • Provides a comprehensive overview of sepsis molecular mechanisms.
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