Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cis-regulatory Sequences02:02

Cis-regulatory Sequences

12.3K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
12.3K
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

4.4K
4.4K
Global Regulatory Systems01:28

Global Regulatory Systems

928
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
928
Evolution of New Traits in Microbes01:24

Evolution of New Traits in Microbes

167
Microorganisms evolve rapidly due to their large population sizes and short generation times, often exhibiting measurable changes within days under laboratory conditions. Natural selection acts on standing genetic variation, enabling the retention and amplification of beneficial traits that confer fitness advantages in changing environments.Adaptive Pigment Regulation in RhodobacterIn Rhodobacter, a genus of purple non-sulfur bacteria, light-harvesting pigments such as bacteriochlorophyll and...
167
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

27.5K
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
27.5K
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

4.4K
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intron location and sequence modulate gene expression in Yarrowia lipolytica.

Nucleic acids research·2026
Same author

CEN-Display: Construction and optimization of a surface display system in Saccharomyces cerevisiae CEN.PK2-1C.

Bioresource technology·2026
Same author

Next-generation brewing yeasts for non-alcoholic beers.

Current opinion in biotechnology·2026
Same author

Designing the future of food fats: precision fermentation of Yarrowia lipolytica for tailored lipid production.

Current opinion in biotechnology·2026
Same author

Beyond natural evolution: multi-scale in vivo mutagenesis toolkits for synthetic evolution.

Trends in biotechnology·2026
Same author

Distinctive domestication of farmhouse beer yeasts preserved pre-industrial genetic and phenotypic diversity.

Current biology : CB·2026

Related Experiment Video

Updated: Apr 16, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.7K

How do regulatory networks evolve and expand throughout evolution?

Karin Voordeckers1, Ksenia Pougach1, Kevin J Verstrepen1

  • 1CMPG Laboratory for Genetics and Genomics, KU Leuven, Gaston Geenslaan 1, B-3001 Leuven, Belgium; VIB Laboratory for Systems Biology, Gaston Geenslaan 1, B-3001 Leuven, Belgium.

Current Opinion in Biotechnology
|February 28, 2015
PubMed
Summary
This summary is machine-generated.

Gene regulatory networks evolve through transcription factor duplication and mutation, leading to new gene functions and network structures. This process allows for adaptation and the emergence of novel biological complexity.

More Related Videos

Quantitative Comparison of cis-Regulatory Element CRE Activities in Transgenic Drosophila melanogaster
08:19

Quantitative Comparison of cis-Regulatory Element CRE Activities in Transgenic Drosophila melanogaster

Published on: December 19, 2011

12.4K
A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

10.9K

Related Experiment Videos

Last Updated: Apr 16, 2026

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.7K
Quantitative Comparison of cis-Regulatory Element CRE Activities in Transgenic Drosophila melanogaster
08:19

Quantitative Comparison of cis-Regulatory Element CRE Activities in Transgenic Drosophila melanogaster

Published on: December 19, 2011

12.4K
A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

10.9K

Area of Science:

  • Evolutionary biology
  • Molecular biology
  • Genetics

Background:

  • Regulatory networks must adapt to new genes and functions during evolution.
  • The molecular mechanisms of gene network evolution are not fully understood.
  • Transcription factor evolution is a key driver of regulatory network changes.

Purpose of the Study:

  • To elucidate the molecular mechanisms behind the evolution of gene regulatory networks.
  • To understand how transcription factor changes contribute to network expansion and adaptation.

Main Methods:

  • Analysis of transcription factor duplication events.
  • Investigating mutations in DNA-binding and interaction domains of transcription factors.
  • Examining the role of promiscuity and modularity in regulatory network evolution.

Main Results:

  • Transcription factor duplication followed by domain-specific mutations drives new network emergence.
  • Promiscuous regulators and target promoters acquire mutations, increasing specificity.
  • Neofunctionalization and subfunctionalization arise from gradual specificity increases.

Conclusions:

  • Transcription factor evolution, particularly through duplication and mutation, is a primary mechanism for gene regulatory network evolution.
  • The inherent flexibility of regulatory networks facilitates adaptation and the development of novel gene functions.