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Immunoregulation by neuroendocrine factors.

I Berczi1

  • 1Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.

Developmental and Comparative Immunology
|January 1, 1989
PubMed
Summary

Early research suggested links between the endocrine system and immunity, but methodological challenges led to neglect. Recent advancements have revived interest in neurohormonal-immune interactions.

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Area of Science:

  • Neuroendocrinology
  • Immunology
  • Psychoneuroimmunology

Background:

  • Initial experimental evidence demonstrated the influence of the pituitary gland and steroid hormones on the lymphoid system over 50 years ago.
  • Early observations also suggested behavioral modification of immunity, but lack of knowledge and methodological issues led to contradictions and disrepute of neurohormonal-immune interactions.
  • The effects of corticosteroids were largely considered pharmacological rather than physiological.

Purpose of the Study:

  • To provide a brief overview of the historical and current state of neurohormonal-immune interactions.
  • To highlight the resurgence of interest in this field of biomedical investigation.

Main Methods:

  • This section is an overview and does not detail specific experimental methods.
  • Relies on referencing previously published literature and experimental findings.

Main Results:

  • The historical context of neurohormonal-immune interactions is presented, including early findings and subsequent decline in research.
  • The past decade has seen a significant revival, establishing neurohormonal-immune interactions as a forefront area of biomedical research.
  • Multiple publications now exist, underscoring the renewed focus on this interdisciplinary field.

Conclusions:

  • The concept of neurohormonal-immune interaction, once in disrepute, is now a major area of contemporary biomedical research.
  • Further investigation is warranted to fully elucidate the complex interplay between the neuroendocrine and immune systems.

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