Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Association of hyperuricemia with valvular heart disease and the modifying effect of obesity.

The Korean journal of internal medicine·2026

Same author

Mesenchymal stem cells derived from human bone marrow ameliorate monosodium urate crystal-induced inflammation.

Biochimica et biophysica acta. Molecular basis of disease·2026

Same author

iPSC-Derived MSC Secretome as a Protective and Restorative Modality for Atopic Dermatitis.

Stem cells international·2026

Same author

Current and future treatment of rheumatoid arthritis.

Journal of rheumatic diseases·2025

Same author

Clinical-grade iPSC-derived chondrogenic micropellets for treating advanced cartilage defects.

Science advances·2025

Same author

Implementing N-terminomics and machine learning to probe Nt-arginylation.

Nature communications·2025

Search research articles

Related Experiment Video

Updated: Apr 16, 2026

Murine Model of Epicutaneously-Induced Immunomodulation

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

Eupatilin ameliorates collagen induced arthritis.

Juryun Kim¹, Youngkyun Kim¹, Hyoju Yi¹

¹Clinical Immunology and STEM (CiSTEM) Cell Laboratory, Convergent Research Consortium for Immunologic Disease, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Journal of Korean Medical Science

|March 3, 2015

Summary

Eupatilin, a key compound in DA-9601, demonstrates anti-inflammatory effects. It reduced arthritis severity and inflammatory markers in a murine model, suggesting potential for treating inflammatory conditions.

Keywords:

Arthritis, Experomental Arthritis, Rheumatoid DA-9601 Eupatilin

More Related Videos

A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model

A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model

Published on: October 30, 2019

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

Related Experiment Videos

Last Updated: Apr 16, 2026

Murine Model of Epicutaneously-Induced Immunomodulation

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model

A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model

Published on: October 30, 2019

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

Area of Science:

Pharmacology
Immunology
Rheumatology

Background:

Eupatilin is the primary active compound in DA-9601, an extract from Artemisia.
Eupatilin has recently shown potential anti-inflammatory properties.

Purpose of the Study:

To investigate the anti-arthritic effects of eupatilin and DA-9601.
To evaluate the impact on inflammatory cytokine expression and osteoclast differentiation.

Main Methods:

Collagen-induced arthritis (CIA) mouse model treated with DA-9601.
Assessment of arthritis scores and osteoclast differentiation.
Measurement of IL-6 and IL-1β mRNA expression in TNF-α stimulated human rheumatoid synoviocytes treated with eupatilin.

Main Results:

DA-9601 administration significantly reduced arthritis scores in CIA mice.
Eupatilin inhibited the expression of IL-6 and IL-1β mRNA in rheumatoid synoviocytes.
Eupatilin demonstrated a dose-dependent reduction in osteoclast formation.

Conclusions:

Eupatilin and DA-9601 exhibit anti-arthritic properties.
These compounds effectively inhibit inflammatory cytokine expression and osteoclast differentiation.
Eupatilin and DA-9601 show promise as anti-inflammatory agents for arthritis treatment.