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Related Experiment Videos

Tardive oculogyric crises.

P M FitzGerald1, J Jankovic

  • 1Department of Neurology, Baylor College of Medicine, Houston, TX 77030

Neurology
|November 1, 1989
PubMed
Summary
This summary is machine-generated.

Tardive oculogyric crises (OGC) can occur after long-term neuroleptic use and are often unrecognized. These involuntary eye movements are part of tardive dystonia and improved with tetrabenazine treatment.

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Area of Science:

  • Movement Disorders
  • Neuropharmacology

Background:

  • Acute dystonic reactions, including oculogyric crises (OGC), are known side effects of dopamine receptor blocking drugs (neuroleptics).
  • The long-term effects of neuroleptics on motor control, particularly tardive syndromes, are a significant area of clinical concern.

Observation:

  • Four patients presented with involuntary ocular deviations (OGC) following prolonged exposure to neuroleptic medications.
  • These patients also exhibited other tardive movement disorders alongside the OGC.
  • The oculogyric crises were persistent and considered a 'tardive' manifestation, distinct from acute reactions.

Findings:

  • The study identifies tardive oculogyric crises (tOGC) as a distinct clinical entity related to chronic neuroleptic use.
  • Tardive OGC were found to be frequently unrecognized and often associated with other tardive movement disorders, suggesting a shared pathophysiology.

Related Experiment Videos

  • All four patients experienced significant improvement in their OGC and other tardive symptoms after treatment with tetrabenazine.

    • Implications:

    • Recognizing tardive OGC is crucial for accurate diagnosis and management of patients on long-term neuroleptic therapy.
    • Tardive OGC should be considered a component of the tardive dystonia spectrum, broadening its clinical presentation.
    • Tetrabenazine appears to be an effective treatment option for tardive OGC and associated movement disorders.