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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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In Vitro Fertilization01:24

In Vitro Fertilization

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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Immunocytochemistry and Immunohistochemistry01:22

Immunocytochemistry and Immunohistochemistry

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Immunocytochemistry (ICC) and immunohistochemistry (IHC) are techniques that use antibodies to check for specific proteins or antigens in a sample. The technique was first published by Albert Coons in 1941 to detect the presence of pneumococcal antigen in tissue sections from mice infected with Pneumococcus. Immunocytochemistry helps localization of proteins or antigens in individual cells like blood cells, stem cells, etc., while immunohistochemistry does the same for tissue samples.
These...
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Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Nursing Clinical Information System01:27

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Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
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Related Experiment Video

Updated: Apr 16, 2026

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
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Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

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To ICSI or Not to ICSI.

Gianpiero D Palermo1, Queenie V Neri1, Zev Rosenwaks1

  • 1Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York.

Seminars in Reproductive Medicine
|March 4, 2015
PubMed
Summary

Intracytoplasmic sperm injection (ICSI) is a popular fertility treatment, especially for male infertility. While safe, ICSI does not improve pregnancy rates over standard IVF in non-male factor cases.

Area of Science:

  • Reproductive Endocrinology
  • Assisted Reproductive Technology
  • Genetics

Background:

  • Intracytoplasmic sperm injection (ICSI) is the primary treatment for severe male factor infertility.
  • Its widespread use has led to comparisons with standard in vitro fertilization (IVF) for non-male factor cases.

Purpose of the Study:

  • To compare the effectiveness of ICSI versus standard IVF in non-male factor infertility.
  • To assess the safety and outcomes of ICSI in children.

Main Methods:

  • Comparative analysis of ICSI and IVF pregnancy rates.
  • Review of follow-up data on ICSI-conceived children, including neonatal and genetic assessments.

Main Results:

  • ICSI does not increase pregnancy rates in non-male factor infertility compared to standard IVF.

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  • ICSI normalizes fertilization in cases of severe male gamete dysfunction.
  • Follow-up studies indicate ICSI is safe, with minor abnormalities linked to parental genetics.

    • Conclusions:

    • ICSI is a valuable tool for male infertility but not superior to IVF for other indications.
    • Further research into sperm biomarkers is needed to optimize insemination method selection.