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Cryopreserved embryo transfer: endometrial preparation and timing
Heather Burks1, Richard Paulson1
1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Seminars in Reproductive Medicine
|March 4, 2015
Summary
Estrogen and progesterone are essential for preparing the endometrium for embryo transfer. Optimal outcomes in cryopreserved embryo transfer depend on precise progesterone timing, not specific regimens.
Area of Science:
- Reproductive Endocrinology
- Assisted Reproductive Technologies
Background:
- Endometrial receptivity is crucial for successful embryo implantation.
- Cryopreserved embryo transfer (CET) requires careful endometrial preparation.
Purpose of the Study:
- To review and synthesize scientific literature on endometrial preparation for CET.
- To formulate expert opinion on optimal endometrial preparation strategies.
Main Methods:
- Critical review of selected scientific literature.
- Synthesis of existing data and expert opinion formulation.
Main Results:
- Estrogen and progesterone are necessary and sufficient for inducing endometrial receptivity.
- Various regimens exist, including natural and artificial cycles.
- Progesterone administration timing must align with embryo developmental stage.
Conclusions:
- No single endometrial preparation regimen or adjuvant has demonstrated superior outcomes in CET.
- Timing of progesterone administration is critical for synchrony.
- Regimen choice may vary based on convenience and administration route.
