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Related Experiment Video

Updated: Apr 16, 2026

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Functional changes in the human auditory cortex in ageing.

Oliver Profant1, Jaroslav Tintěra2, Zuzana Balogová1

  • 1Department of Auditory Neuroscience, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic; Department of Otorhinolaryngology and Head and Neck Surgery, 1st Faculty of Medicine, Charles University in Prague, University Hospital Motol, Prague, Czech Republic.

Plos One
|March 4, 2015
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Summary
This summary is machine-generated.

Ageing hearing loss (presbycusis) involves central auditory pathways. Elderly individuals show increased, right-sided auditory cortex activation compared to younger adults, potentially compensating for hearing decline.

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Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Gerontology

Background:

  • Age-related hearing loss, or presbycusis, is a common sensory decline affecting the ageing population.
  • Presbycusis is characterized by impaired temporal sound processing and reduced speech perception, suggesting a central auditory system component.
  • Understanding the central mechanisms of presbycusis is crucial for addressing age-related auditory deficits.

Purpose of the Study:

  • To investigate the functional changes in the auditory cortex associated with presbycusis using functional magnetic resonance imaging (fMRI).
  • To compare auditory cortex activity between young adults and elderly individuals with varying degrees of hearing loss.
  • To explore potential age-related compensatory mechanisms within the central auditory system.

Main Methods:

  • Functional MRI (fMRI) was employed to measure blood-oxygen-level-dependent (BOLD) activity in the auditory cortex.
  • Two groups of elderly subjects (>65 years) with mild (MP) and expressed presbycusis (EP), and a group of young subjects (<30 years) were studied.
  • Auditory cortex responses to acoustically evoked stimuli across various frequencies were recorded and analyzed for activation patterns and lateralization.

Main Results:

  • Elderly participants, regardless of presbycusis severity, exhibited greater auditory cortex activation in temporal lobes compared to young controls.
  • A notable rightward asymmetry in temporal lobe activation was observed in both elderly groups, contrasting with leftward lateralization in young subjects.
  • No significant differences in auditory cortex activation were found between the mild and expressed presbycusis groups.

Conclusions:

  • Increased and right-lateralized auditory cortex activation in elderly individuals may represent a compensatory mechanism for age-related auditory processing impairments.
  • The findings highlight the involvement of central auditory pathways in presbycusis, beyond peripheral hearing thresholds.
  • Further research is warranted to elucidate the neural basis of auditory compensation in ageing.