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Complement activation promotes colitis-associated carcinogenesis through activating intestinal IL-1β/IL-17A axis.

C Ning1,2, Y-Y Li3, Y Wang1

  • 1Department of Immunology, Institute of Basic Medical Sciences, Beijing, China.

Mucosal Immunology
|March 5, 2015
PubMed
Summary

Complement activation drives colitis-associated colorectal cancer (CAC) by increasing IL-1β and IL-17. Targeting complement pathways may offer new treatments for this inflammatory bowel disease complication.

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