Related Experiment Video
Updated: Apr 16, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
Published on: August 15, 2025
Language lateralization in a patient with temporal lobe epilepsy and callosal agenesis
Taoufik Alsaadi1, Tarek M Shahrour2
1Department of Neurology, SKMC, United Arab Emirates.
Abstract:
The corpus callosum has been proposed as a mechanism of interhemispheric inhibition that allows language dominance to develop [1]. Callosal agenesis or dysgenesis provides a test of this hypothesis, as patients lacking a normal corpus callosum should also lack normal language lateralization [2]. We report pre- and postoperative functional magnetic resonance imaging (fMRI) and neuropsychological testing in a patient with partial callosal agenesis who underwent a right temporal lobectomy for medically refractory seizures.
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