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MicroRNA-125b is involved in atherosclerosis obliterans in vitro by targeting podocalyxin

Xiaobing Li1, Na Yao1, Juan Zhang1

  • 1Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.

Molecular Medicine Reports
|March 5, 2015
PubMed

Insights

MicroRNA-125b (miR-125b) suppresses vascular cell proliferation and migration by targeting Podocalyxin (PODXL). This finding highlights miR-125b as a potential therapeutic target for arteriosclerosis obliterans.

Area of Science:

  • Cardiovascular biology
  • Molecular biology
  • Cellular biology

Background:

  • Cardiovascular diseases, driven by oxidative stress and atherosclerosis, are a leading global cause of death.
  • Accelerated vascular smooth muscle cell proliferation and migration, along with endothelial dysfunction, are key features of atherogenesis.
  • MicroRNAs (miRNAs) play a critical role in cardiovascular system regulation.

Purpose of the Study:

  • To investigate the relationship between miR-125b and Podocalyxin (PODXL) in vascular cells.
  • To determine the functional role of miR-125b in cell proliferation and migration.
  • To explore the potential of miR-125b as a therapeutic target for arteriosclerosis obliterans.

Main Methods:

  • Analyzing the association between miR-125b and PODXL in human umbilical vein endothelial cells and human aortic vascular smooth muscle cells (HAVSMCs).
  • Treating cells with oxidized low-density lipoprotein (LDL) and platelet-derived growth factor.
  • Evaluating the suppressive function of miR-125b on cell proliferation and migration in HAVSMCs.

Main Results:

  • An inverse association was observed between miR-125b and PODXL in treated vascular cells.
  • miR-125b demonstrated a suppressive effect on cell proliferation and migration, partly by targeting PODXL.
  • miR-125b's function in arteriosclerosis obliterans may involve interactions with transgelin, LOX-1, VE-cadherin, ICAM-1, IL-6, and MCP-1.

Conclusions:

  • miR-125b plays a significant role in arteriosclerosis obliterans by inhibiting PODXL expression.
  • miR-125b emerges as a potential therapeutic target for treating arteriosclerosis obliterans.

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