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Published on: April 17, 2012
Successful Pregnancy and Delivery After Radiation With Ovarian Shielding for Acute Lymphocytic Leukemia Before
Naoya Ishibashi1, Toshiya Maebayashi, Takuya Aizawa
1Departments of *Radiology §Pediatrics and Child Health, Nihon University School of Medicine, Itabashi †Radiology Clinic, Saonoda Medical Corporations, Adachi, Tokyo ‡Department of Radiation Oncology, Kawasaki Saiwai Hospital, Kawasaki, Kanagawa, Japan.
Abstract:
Total body irradiation is performed as a preconditioning regimen to inhibit graft-versus-host disease after bone marrow transplantation and to eradicate remaining tumor cells. However, these regimens result in delayed secondary sex characteristics and failure of ovarian function recovery, leading to amenorrhea and infertility. Herein, we report a case of an 11-year-old girl diagnosed with acute lymphocytic leukemia who received induction chemotherapy and prophylactic cranial irradiation. For bone marrow transplantation, she received total body irradiation of 12 Gy with uterine and ovarian shielding at 13 years of age. The patient remained in remission and menarche began at 14 years of age. At 23, she became pregnant and delivered a baby naturally with no abnormalities.
