[Modern polymers in matrix tablets technology]

Area of Science:

• Pharmaceutical Technology
• Materials Science

Background:

• Matrix tablets are a popular oral drug delivery method.
• Polymeric materials are crucial for modulating drug release rates.
• The goal is to achieve sustained in vivo plasma drug concentrations.

Purpose of the Study:

• To review polymers used in matrix tablet technology.
• To provide examples of polymer applications in matrix tablets.

Main Methods:

• Literature review of polymers in matrix tablet formulations.
• Discussion of synthetic and natural polymer applications.
• Inclusion of emerging technologies like 3D printing.

Main Results:

• Cellulose derivatives (e.g., hydroxypropyl methylcellulose - HPMC) are common matrix formers.
• Other synthetic polymers include Kollidon SR, Eudragits, and Carbopols.
• Natural polymers like carragens, chitosan, and alginates are gaining pharmaceutical importance.

Conclusions:

• Various synthetic and natural polymers are effective in matrix tablet formulations.
• 3D printing offers new possibilities for matrix tablet design.
• Continued research into novel polymers will advance controlled drug delivery.