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Related Concept Videos

Atypical Pneumonia01:14

Atypical Pneumonia

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Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
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Diphtheria01:28

Diphtheria

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Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
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Pneumonia II: Pathophysiology01:29

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The pathophysiology of pneumonia involves the following steps:
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Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Acute Respiratory Failure-II01:21

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Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
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Related Experiment Video

Updated: Apr 16, 2026

An Ex vivo Mast Cell Degranulation Assay using Crude Peritoneal Exudate Cells and Natural Antigen Stimulation
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Daptomycin-induced acute eosinophilic pneumonia.

Jayshil J Patel, Agith Antony, Maria Herrera

    WMJ : Official Publication of the State Medical Society of Wisconsin
    |March 6, 2015
    PubMed
    Summary

    Daptomycin can cause acute eosinophilic pneumonia, a rare but serious side effect. Prompt recognition and discontinuation of daptomycin led to full recovery in a patient with this condition.

    Area of Science:

    • Pharmacology
    • Pulmonology
    • Infectious Diseases

    Background:

    • Daptomycin, a lipopeptide antibiotic, is effective against Gram-positive bacteria.
    • Acute eosinophilic pneumonia is a rare, potentially fatal adverse drug reaction associated with daptomycin use.
    • Prompt recognition and management are crucial for favorable outcomes.

    Observation:

    • A patient with calcaneal osteomyelitis developed symptoms of respiratory distress, fever, and cough after initiating daptomycin therapy.
    • Upon re-initiation of daptomycin, the patient experienced hypoxemic respiratory failure, pulmonary infiltrates, and peripheral eosinophilia.
    • Bronchoscopic lavage confirmed a significant presence of eosinophils (30%).

    Findings:

    • The patient was diagnosed with definite daptomycin-induced acute eosinophilic pneumonia.

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  • Discontinuation of daptomycin resulted in complete resolution of respiratory symptoms, eosinophilia, and radiographic abnormalities.
  • This case represents the eighth definite instance reported in the literature.

    • Implications:

    • This case highlights the importance of considering daptomycin-induced acute eosinophilic pneumonia in patients presenting with compatible respiratory symptoms.
    • Increased awareness and prompt diagnosis can prevent severe complications and ensure patient recovery.
    • Further vigilance is warranted given the expanding clinical applications of daptomycin.