Related Experiment Video
Updated: Apr 16, 2026
10:28
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
13.5K
Bisphosphonate-modified biomaterials for drug delivery and bone tissue engineering
1Uppsala University, Division of Polymer Chemistry, Department of Chemistry-Ångström, Science for Life Laboratory , Uppsala, SE 751 21 , Sweden +46 18 417 7335 ; Dmitri.ossipov@kemi.uu.se.
Expert Opinion on Drug Delivery
|March 6, 2015
Summary
Bisphosphonates (BPs) are now used in bone tissue engineering by chemically immobilizing them into hydrogels and nanocomposites. This innovation enhances bone targeting and therapeutic delivery for bone disease treatments.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Nanotechnology
Background:
- Bisphosphonates (BPs) have a 45-year history as anti-osteoporotic drugs.
- BPs are increasingly used for bone targeting in systemic treatments.
- Recent advancements involve immobilizing BPs in hydrogels and nanocomposites for bone tissue engineering.
Purpose of the Study:
- To explore novel applications of bisphosphonates (BPs) in bone tissue engineering.
- To review strategies for chemically immobilizing BPs in advanced materials.
- To discuss the therapeutic potential of BP-modified drug delivery systems.
Main Methods:
- Conjugation of BPs to various molecules (drugs, imaging agents, polymers).
- Development of hydrogel scaffolds and nanocomposites incorporating BP conjugates.
- Evaluation of bone targeting and therapeutic effects of BP-prodrugs.
Main Results:
- BP conjugation successfully extends calcium-binding properties for bone targeting.
- Supramolecular assemblies create novel nanocarriers and nanocomposite scaffolds.
- BP-functionalized nanomaterials exhibit bone-targeting properties analogous to bulk materials.
Conclusions:
- Chemical immobilization of BPs in hydrogels and nanocomposites opens new avenues in bone tissue engineering.
- Conjugation strategies enhance bone targeting and enable controlled drug delivery.
- BP-based materials offer promising solutions for bone regeneration and disease treatment.
Related Concept Videos
01:31Bone Remodeling and Repair
10.7K
10.7K
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
132
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
132
01:40Bone Remodeling
41.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
41.3K
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
108
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
108
01:31Essential Minerals for Bone Health
7.4K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
7.4K
01:24Modified-Release Drug Delivery Systems: Site-Targeted
144
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
144