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Updated: Apr 16, 2026

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
Published on: March 24, 2017
Getting it right for children: improving tuberculosis treatment access and new treatment options
Grania Brigden1, Jennifer Furin, Clara Van Gulik
1Medecins Sans Frontieres, Rue de Lausanne 78, P.O Box 116, Geneva, Switzerland.
Insights
Children with tuberculosis (TB) are no longer forgotten. With increased awareness and improved management strategies, most childhood TB cases are diagnosable and treatable, leading to excellent outcomes.
Area of Science:
- Pediatrics
- Infectious Diseases
- Public Health
Background:
- Children have historically been overlooked in global tuberculosis (TB) control efforts.
- Both traditional TB services and maternal/child health programs have often failed to adequately address pediatric TB.
- There is a growing recognition of the need for focused attention on the optimal management of TB in children.
Purpose of the Study:
- To address the misconception that diagnosing and treating TB in children is always difficult.
- To review current diagnostic and management approaches for pediatric TB.
- To highlight advancements and necessary actions to prevent unnecessary child mortality from TB.
Main Methods:
- Literature review of current diagnostic tools and treatment outcomes for pediatric TB.
- Analysis of strategies to improve healthcare worker training and integration into childhood illness management.
- Overview of recent advances in the field of pediatric TB.
Main Results:
- Despite the need for new diagnostics, most childhood TB cases in high-burden settings are manageable with existing tools.
- Treatment outcomes for pediatric TB are generally excellent when diagnosed and treated appropriately.
- Increased TB awareness and integrated care strategies can significantly improve access and quality of care.
Conclusions:
- Pediatric TB requires dedicated focus and improved healthcare strategies.
- Effective diagnosis and treatment are achievable with current approaches, challenging the notion of inherent difficulty.
- Continued efforts in awareness, training, and integrated care are crucial to eliminate preventable deaths from TB in children.
Abstract:
Children were often the forgotten victims of the global tuberculosis (TB) epidemic, neglected by traditional TB services as well as maternal and child health initiatives. Luckily this is changing with a greater focus on children and the issues regarding their optimal management. A common misconception is that children with TB are always difficult to diagnose and treat. New diagnostic tools are urgently needed, but most children with TB in high-burden settings can be diagnosed with available approaches and treatment outcomes are generally excellent. Increased TB awareness, appropriate training of health care workers and inclusion in integrated management of childhood illness strategies will improve the access and quality of care that children receive. This review highlights what needs to be done to ensure that no child unnecessarily dies from TB and provides a brief overview of new advances in the field.
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