(18)FDG PET/CT appearance in primary cutaneous diffuse large B-cell lymphoma, leg type

Area of Science:

• Dermatology
• Oncology
• Pathology

Background:

• Primary cutaneous lymphomas are a heterogeneous group of non-Hodgkin lymphomas.
• Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDBCL-LT) is a rare and aggressive subtype.

Observation:

• A 70-year-old woman presented with a rapidly enlarging, painless red skin nodule on her right lower leg.
• The lesion developed a central eschar within weeks of onset.

Findings:

• Skin biopsy confirmed PCDBCL-LT.
• F-FDG PET/CT revealed a localized, hypermetabolic soft tissue mass without systemic involvement.

Implications:

• Early recognition and diagnosis of PCDBCL-LT are crucial due to its aggressive nature.
• Localized disease on PET/CT suggests potential for curative-intent therapy.
• This case highlights the importance of thorough dermatopathological evaluation for unusual skin lesions.