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[Desperately seeking targets]
1UMR 7268 ADÉS, Aix-Marseille, Université/EFS/CNRS, Espace éthique méditerranéen, hôpital d'adultes la Timone, 264, rue Saint-Pierre, 13385 Marseille Cedex 05, France ; CoReBio PACA, case 901, parc scientifique de Luminy, 13288 Marseille Cedex 09, France.
Abstract:
In clinical oncology, obtaining sequence data from tumour samples has become practical in terms of logistics, turnover time and costs. The major issue now is the interpretation of this sequence to define actionable targets, i.e. genome changes that are involved in tumorogenesis and that predict the efficacy of existing and available targeted treatments. This is the focus of major efforts from public clinical centres and from companies that see it as a promising commercial activity.
Insights
Interpreting clinical tumor sequencing data is crucial for identifying actionable targets. This helps predict patient response to targeted cancer therapies, driving research and commercial development.
Area of Science:
- Oncology
- Genomics
- Bioinformatics
Context:
- Tumor sequencing is now logistically feasible, fast, and cost-effective in clinical settings.
- The primary challenge in clinical oncology has shifted from data acquisition to data interpretation.
- Significant efforts are underway by public institutions and private companies to address this challenge.
Purpose:
- To interpret complex tumor genomic data and identify actionable targets.
- To define genomic alterations driving tumor development (tumorogenesis).
- To predict the efficacy of targeted therapies based on tumor genetic profiles.
Summary:
- Obtaining tumor sequence data is now practical in clinical oncology.
- The key challenge is interpreting this data to find actionable targets.
- These targets are genome changes involved in tumorogenesis and predicting treatment response.
Impact:
- Enables personalized medicine through targeted treatment selection.
- Facilitates the development of novel targeted therapies.
- Drives commercial innovation in clinical bioinformatics and diagnostics.