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Updated: Apr 16, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Cardiological aspects of stroke prevention
1Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Insights
Cardiologists should stay updated on stroke prevention for cardiac patients. New oral anticoagulants reduce stroke risk in atrial fibrillation (AF) compared to warfarin.
Area of Science:
- Cardiology
- Neurology
- Stroke Medicine
Background:
- Cardiac disorders increase stroke risk (ischemic and hemorrhagic).
- Atrial fibrillation (AF) is a primary cardiac cause of ischemic stroke (IS).
- Occult AF detection rises with implantable cardiac monitors post-IS.
Purpose of the Study:
- To inform cardiologists about advances in stroke prevention for cardiac patients.
- To review stroke risk factors and prevention strategies in various cardiac conditions.
Main Methods:
- Review of current literature on cardiac disorders and stroke risk.
- Analysis of new oral anticoagulants versus warfarin for stroke prevention in AF.
- Evaluation of stroke risk in specific conditions like cardiomyopathy and patent foramen ovale.
Main Results:
- New oral anticoagulants show reduced IS and intracerebral hemorrhage risk versus warfarin in AF.
- Implantable monitors improve detection of AF after IS.
- Stroke risk is elevated in patients with cardiomyopathy, valve replacement, myocardial infarction, aortic atheroma, and PFO.
Conclusions:
- New oral anticoagulants offer improved safety and efficacy for stroke prevention in AF.
- Optimal IS prevention strategies for non-AF cardiac disorders require further research and individualized approaches.
- Cardiologists must integrate stroke prevention into the management of diverse cardiac conditions.
Abstract:
Many cardiac disorders and their treatment are associated with an increased risk for ischemic or hemorrhagic stroke, so it is important for cardiologists to be aware of recent advances in the field of stroke prevention. Atrial fibrillation (AF) is the most common cardiac disorder associated with a substantial risk for ischemic stroke (IS). The availability of implantable cardiac monitoring devices has substantially increased the detection rate of occult AF after IS. The 4 new oral anticoagulants have advantages when compared with warfarin, the standard therapy in AF to prevent IS, demonstrating a reduced risk for IS or intracerebral hemorrhage. Patients with cardiomyopathy, cardiac valve replacement, recent myocardial infarction, larger aortic arch atheroma and patent foramen ovale all have some level of increased risk for IS. The best approach for IS prevention in these disorders remains unsettled and varying approaches are recommended.
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