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Published on: January 3, 2013
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Sex differences in immunohistochemical expression and capillary density in pancreatic solid pseudopapillary neoplasm
Kenichi Hirabayashi1, Sachiko Kurokawa2, Atsuko Maruno3
1Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Annals of Diagnostic Pathology
|March 7, 2015
Summary
Solid pseudopapillary neoplasm (SPN) is rare, predominantly affecting young women. While SPN shows some sex-specific histopathological differences like fibrous capsules and cholesterol clefts, most features are similar between men and women.
Area of Science:
- Oncology
- Pathology
- Gastroenterology
Background:
- Solid pseudopapillary neoplasm (SPN) is a rare, low-grade malignant pancreatic tumor.
- SPN predominantly affects young women, with a lower incidence in men.
Purpose of the Study:
- To investigate potential sex differences in the clinical histopathology of SPN.
- To compare capillary density and immunohistochemical marker expression between male and female SPN patients.
Main Methods:
- Histopathological and immunohistochemical analysis of 22 resected pancreatic SPN tumors (16 women, 6 men).
- Evaluation of markers including synaptophysin, β-catenin, hormone receptors, Ki-67, CD10, CD31, and glypican 3.
- Assessment of capillary density and specific histopathological features like fibrous capsules and cholesterol clefts.
Main Results:
- Women were significantly younger (median 24 years) than men (median 52.5 years).
- Fibrous capsules (69%) and cholesterol clefts (63%) were significantly more common in women's tumors.
- No significant sex differences were observed in tumor size, necrosis, lymphovascular invasion, perineural invasion, or glypican 3 expression.
Conclusions:
- While SPN occurs more frequently in women and exhibits some distinct histopathological features (fibrous capsule, cholesterol clefts) and younger age at diagnosis, core histopathologic and immunohistochemical characteristics show limited sex-based variation.
- These findings contribute to understanding the nuances of SPN in different sexes.
