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Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Related Experiment Video

Updated: Apr 16, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

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Stem cell collection considerations for AL amyloidosis.

Eric A Gehrie, Garrett S Booth

    Connecticut Medicine
    |March 10, 2015
    PubMed
    Summary

    Autologous stem cell transplants offer new hope for amyloidosis patients. For those with cardiac amyloidosis, substituting heparin for citrate during stem cell collection may improve outcomes.

    Area of Science:

    • Hematology
    • Cardiology
    • Oncology

    Background:

    • Amyloidosis is a progressive condition often linked to adverse clinical outcomes.
    • Advancements in treatment strategies are expanding eligibility for autologous stem cell transplantation (ASCT).

    Observation:

    • This report details a case of ASCT in a patient diagnosed with systemic amyloidosis.
    • It highlights specific considerations for peripheral blood stem cell (PBSC) collection in this patient population.

    Findings:

    • The study suggests that heparin may be a viable alternative to citrate in PBSC collection for patients with cardiac amyloidosis.
    • This substitution should be considered when no contraindications to heparin exist.

    Implications:

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  • This finding could enhance the safety and efficacy of ASCT for patients with cardiac amyloidosis.
  • It offers a potential modification to standard PBSC collection protocols to better suit specific patient profiles.