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Updated: Apr 16, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates

Published on: February 27, 2016

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Multifaceted Modulation of SIRT1 in Cancer and Inflammation

Hui Yang1, Yujing Bi2, Lixiang Xue3

  • 1Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai China; Biotherapy Research Center, Institute of Immunobiology, Fudan University.

Critical Reviews in Oncogenesis
|March 10, 2015
PubMed

Insights

Sirtuin 1 (SIRT1) is a key enzyme regulating inflammation and cancer. It influences immune responses and acts as both an oncoprotein and tumor suppressor, offering potential for novel cancer therapies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Immunology

Background:

  • Sirtuin 1 (SIRT1) is a NAD+-dependent deacetylase involved in numerous cellular processes.
  • SIRT1 targets both histone and non-histone proteins, impacting signaling pathways.
  • Evidence links SIRT1 to lifespan, DNA repair, metabolic stress, inflammation, and cancer.

Purpose of the Study:

  • To review the role of SIRT1 in immune responses.
  • To discuss the dual role of SIRT1 in tumorigenesis.
  • To explore SIRT1's impact on the tumor microenvironment for therapeutic insights.

Main Methods:

  • Literature review of studies on SIRT1 function.
  • Analysis of SIRT1's deacetylase activity on various substrates.
  • Examination of SIRT1's involvement in inflammatory and cancer pathways.

Main Results:

  • SIRT1 modulates immune cell responses by deacetylating transcription factors.
  • SIRT1 exhibits context-dependent roles in cancer, acting as an oncoprotein or tumor suppressor.
  • SIRT1 affects both cancer cells and immune cells within the tumor microenvironment.

Conclusions:

  • SIRT1 is a critical regulator of inflammation and immunity.
  • Understanding SIRT1's complex role in cancer is crucial for developing targeted therapies.
  • SIRT1-based strategies may offer new avenues for cancer treatment by modulating the tumor microenvironment.

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